Download Autodock Tools Work Patched Jun 2026

AutoDock is the core "engine" that performs the molecular docking calculation, predicting how a small molecule (ligand) will bind to a protein (receptor). AutoDock Tools (ADT), provided through the MGLTools package, is the graphical user interface (GUI) that allows you to prepare your molecules, set up docking parameters, and analyze the results visually.

Choose your search algorithm (the is the standard choice).

Choose an installation directory. Tip: Avoid paths with spaces (like C:\Program Files\ ). Instead, install directly to C:\MGLTools\ to prevent pathway errors in command lines.

Place these executable files into an easily accessible directory on your computer. Linking the Engines to ADT AutoDock is the core "engine" that performs the

Load your small molecule file, detect its rotatable bonds (torsions), assign proper charges, and export it as a .pdbqt file.

Go to File > Read Molecule and try loading a standard .pdb file. If the molecule displays visually without crashing the program, your installation is fully functional. Troubleshooting Common Errors 1. PMV or ADT Crashes on Startup (Graphics Issues) Instead, install directly to C:\MGLTools\ to prevent pathway

If you need the latest AutoDock-GPU or AutoDock Vina, you may need to download those separately, but ADT remains the standard preparation tool.